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| The clinical significance of TBP2 and BMP15 levels in autoimmune premature ovarian failure |
| 1. Guangming Hospital of Traditional Chinese Medicine of Pudong New Area, Shanghai, 201399; 2.Chongming Branch of Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University |
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Abstract Objective: To investigate the expressions and clinical significance of thioredoxin binding protein-2 (TBP2) and bone morphogenetic protein 15 (BMP15) in autoimmune premature ovarian failure (POF). Methods: 48 women with autoimmune POF were selected in study group, and 48 healthy women with normal ovarian function were selected in control group during the same period. The enzyme linked immunosorbent assay (ELISA) was used to detect the expression levels of TBP2 and BMP15 of all subjects, and the levels of sex hormone was detected by Abbott I2000 chemiluminescence analyzer. The clinical significance of the changes of the levels of TBP2 and BMP15 in autoimmune POF was analyzed. Results: The levels of TBP2 and BMP15, and the level of estradiol (E2) of women in the study group were significant lower than those of women in the control group (P<0.05), but the levels of follicle stimulating hormone (FSH) and luteinizing hormone(LH) of women in the study group were significant higher (all P<0.05). In the study group, the expressions of TBP2 and BMP15 were negatively correlated with the levels of FSH and LH, but were positively correlated with the level of E2(P<0.05). There was a positive correlation between TBP2 expression and BMP15 expression (P=0.000). Conclusion: The expression levels of TBP2 and BMP15 of women with autoimmune POF are down-regulated, and there is a positive correlation between the TBP2 expression and the BMP15 expression. And the expression levels of TBP2 and BMP15 is closely related to the levels of sex hormone, which means TBP2 level and BMP15 level maybe synergistically regulate the pathogenesis of autoimmune POF.
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