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| The relationship between the levels of TGF-β, VEGF and ICAM-1 of women with endometriosis and their clinical staging of endometriosis |
| 1.Jintan District People's Hospital, Changzhou, Jiangsu Province, 213200；2 The Second People's Hospital of Changzhou |
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Abstract Objective: To observe the levels of fibroblast growth factor-β(TGF-β), VEGF and ICAM-1 of women with endometriosis, and to analyze their clinical significance. Methods: 100 women with endometriosis were enrolled in study group, and 100 healthy women were selected in control group from February to February 2018. The levels of TGF-β, VEGF and ICAM-1 of women were compared between the two groups, and the levels of TGF-β, VEGF and ICAM-1 of women with different clinical staging of endometriosis were observed. Pearson correlation analysis was used to analyze the correlation between TGF-β level and the levels of VEGF and ICAM-1 of women in the study group. Results: The levels of TGF-β, VEGF and ICAM-1 of women in the study group were 389.25±12.36pg/ml, 178.45±10.02pg/ml, and 186.34±13.15μg/ml, respectively, which were significant higher than those (322.16±15.04pg/ml, 120.27±8.45pg/ml, 104.28±12.93μg/ml, respectively) of women in the control group. In the study group, the levels of TGF-β, VEGF and ICAM-1 of women with endometriosis clinical stage III-IV were 411.35±12.95pg/ml, 192.92±8.35pg/ml, 204.15±15.17μg/ml, respectively, which were significant higher than those (352.94±15.24pg/ml, 155.36±7.28pg/ml, and 168.28±10.02μg/ml, respectively) of women with endometriosis clinical stage I-II (all P<0.001). TGF-β level of women in the study group was positively correlated with their VEGF and ICAM-1 levels (r=0.523, 0.489, P<0.05). Conclusion: The levels of TGF-β, VEGF and ICAM-1 of women with endometriosis have increased, and which’s TGF-β level is positively correlated with their VEGF and ICAM-1 levels.
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