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| The influence of severe spontaneous vacuolation on the potential of embryonic development after insemination |
| Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030 |
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Abstract Objective: To investigate the influence of severe spontaneous vacuolation on the potential of embryonic development on the 5th day (D5) after insemination. Methods: The clinical data of the women experienced in vitro fertilization and embryo transfer (IVF-ET) or intracytoplasmic sperm injection (ICSI) from January 2016 to December 2017 were retrospective analyzed. 873 embryos with severe spontaneous vacuolation on the D5 after insemination were selected in study group, and 5709 embryos without abnormal morphology were randomly selected in control group. The blastocyst rate, high quality blastocyst rate, and clinical outcomes of women on the 6th day (D6) after insemination were compared between the two groups. Results: The blastocyst rate and high quality blastocyst rate of women in the study group were 8.3% and 22.2%, which were significant lower than those(27.9% and 65.2%) of women in the control group (P<0.05). In terms of clinical outcomes, there were no significant different in pregnancy rate and live birth rate of women after embryo transfer with single embryo resuscitation or combined resuscitation with normal embryos between the two groups (P>0.05). Conclusion: Although the formation of severe spontaneous vacuolation on the D5 after insemination can affect the blastocyst available rate and highquality blastocyst rate on the D6, the blastocyst available rate of women with the formation of severe spontaneous vacuolation on the D5 after insemination has the similar clinical outcomes of women without abnormal morphology of embryos.
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