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| The value of serum brain natriuretic peptide and troponin I levels for predicting adverse maternal and infant outcomes of pregnant women with heart disease |
| General Hospital of the Northern War Zone，Shenyang, Liaoning Province, 11000 |
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Abstract Objective: To explore the value of serum brain natriuretic peptide (BNP) and troponin I (cTnI) levels for predicting adverse maternal and infant outcomes of pregnant women with heart disease. Methods: 64 pregnant women with heart disease were divided into group A (34 women with good pregnancy outcomes) and group B (30 women with adverse pregnancy outcomes). Serum BNP and cTnI levels of all women were measured during the third trimester of pregnancy (28 and 32 gestational weeks). The serum BNP and cTnI levels and cardiac function grading before delivery of women were compared between the two groups. Results: Compared with those of women during 28 gestational weeks in the two groups, the levels of serum BNP and cTnI were significant higher during 32 gestational weeks. The levels of serum BNP and cTnI of women in the group A during 32 gestational weeks were significant lower than those of women in group B (P<0.05). The proportion of grade I and II of women in group A was significant higher than that of women in group B, but the proportion of grade III and IV of women in group A was significant lower (P<0.05). The values increased of serum BNP and cTnI levels of pregnant women in both groups were positively correlated with their NYHA grade(r=0.910, 0.895, P<0.05). There was no significant difference in diagnostic sensitivity, specificity and accuracy for predicting adverse maternal and infant outcomes between serum BNP level and serum cTnI level (P>0.05). The AUC value, the sensitivity, the specificity, and the accuracy of the BNP level combined with the cTnI level detection were 0.841, 94.6%, 98.2% and 96.4%,respectively, which were significant higher than those of detection of serum BNP level or cTnI level alone (P<0.05). Conclusion: The levels of serum BNP and cTnI of pregnant women with heart disease increase during the third trimester of pregnancy, which is closely related to their adverse maternal and infant outcomes. Monitoring serum BNP and cTnI levels of pregnant women can predict effectively the occurrence of adverse maternal and infant outcomes.
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