Abstract Objective: To investigate the blood pressure value and blood pressure variability of pregnant women with subclinical hypothyroidism during the third trimester of pregnancy. Methods: A total of 280 pregnant women with subclinical hypothyroidism were enrolled in study group from January 2016 to January 2019, and 280 normal pregnant women were selected in control group during the same period. 24h ambulatory blood pressure monitor was used to observe blood pressure and blood pressure variability 24h all day, from 6:00 to 10:00 during the day and from 22:00 to 6:00 the next day of all pregnant women during 34-36 gestational weeks. Results: The incidence of gestational hypertension and TSH level of women in the study group were significant higher than those of women in the control group, but the FT3 level of women in the study group was significant lower (P<0.05). The values of systolic blood pressure (SBP), diastolic blood pressure (DBP), systolic blood pressure coefficient of variation (SCV), diastolic blood pressure coefficient of variation (DCV), systolic blood pressure standard deviation (SSD), and diastolic blood pressure standard deviation (DSD) in 24h all day from 6:00 to 10:00 or from 22:00 to 6:00 the next day of women in the study group were all significant higher than those of women in the control group (P<0.05). In the study group, the values of SBP, DBP, SCV, DCV, SSD and DSD of women in 24h all day were positively correlated with their TSH level, and the values of SBP, SCV, SSD and DSD of women in 24h all day were negatively correlated with their FT3 level (P<0.05). Conclusion: Pregnant women with subclinical hypothyroidism has a high incidence of pregnancy induced hypertension, their blood pressure and blood pressure variability during pregnancy are higher, and their degree of blood pressure fluctuation is large, so they should be given more attention to and were given intervention treatment timely in clinical practice.
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