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Abstract Objective: To explore the clinical value of reference range of blood glucose index of women without pregnancy used for evaluating healthy pregnant women, and to establish the normal reference range of blood glucose index of healthy pregnant women. Methods: The total of 750 pregnant women were selected as subjects, and were divided in group A (250 women during the first trimester of pregnancy), in group B (250 women during the second trimester of pregnancy), and group C (250 women during the third trimester of pregnancy) from January 2016 to December 2018. Another 250 healthy women without pregnancy were selected in group D. Fasting blood glucose level of women in the four groups were measured. Results: K-S test showed that the blood glucose level of women in the four groups had showed normal distribution (P>0.05). Fasting blood glucose level of women in group A, B and C was significant higher than that of women in group D (P<0.05), and the fasting blood glucose level of women in group B and C was significant higher than that of women in group A (P<0.05), but the fasting blood glucose level of women in group B had no significant different to that of women in group C (P>0.05). There was no significant different in blood glucose level of women in the four groups among women with different age (P<0.05). After calculated based on x±1.96s, the reference range of blood glucose level of women in group D, A, B and C were 4.02-5.40mmol/L, 3.91-5.83mmol/L, 4.32-5.97mmol/L, and 4.33-6.05mmol/L, respectively. Conclusion: It is unreasonable to evaluate the blood glucose level of pregnant women based on the reference range of blood glucose index of women without pregnant. The normal reference range of blood glucose index of pregnant women should be established in clinical practice, which can provide scientific evidence for early detection, prevention and intervention of GDM.
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