|
|
|
| The relationship between the TIMP-2 and G-CSF levels and chorioamnionitis of women with premature rupture of membranes |
| Jiaozhou Central Hospital, Qingdao, Shangdong Province, 266300 |
|
|
|
|
Abstract Objective: To investigate the relationship between the tissue inhibitor of metalloproteinase -2 (TIMP-2) and granulocyte colony stimulating factor (G-CSF) levels and chorioamnionitis of women with premature rupture of membranes. Methods: 83 women with premature rupture of membranes were selected i observation group, and 83 normal healthy pregnant women with full-term delivery were included in control group from March 2017 to February 2019. The levels of TIMP-2 and G-CSF in the embryolemma tissue of women in the two groups were detected. According to the results of laboratory indications and clinical examination, the pregnant women in the observation group were further divided into 3 groups, which included group A (24 women without chorioamnionitis), group B (29 women with laboratory indications and without clinical symptoms), and group C (30 women with chorioamnionitis). The levels of TIMP-2 and G-CSF of women were compared among the four groups, and the relationship between TIMP-2 and G-CSF levels and the severity degree of chorioamnionitis of women were analyzed. Results: The expression level of TIMP-2 of women in the observation group was significant higher than that of women in the control group, but the level of G-CSF of women in the observation group was significant lower (P<0.05). In the observation group, the level of TIMP-2 in group A was the highest, but the level of TIMP-2 was the lowest. The TIMP-2 level was negative ly correlated with the rate of chorioamnionitis of women with premature rupture of membranes (r=-0.647, P<0.05), but the G-CSF level was positively correlated with the rate of chorioamnionitis of women with premature rupture of membranes (r=0.657, P<0.05). Conclusion: TIMP-2 and G-CSF levels in embryolemma tissue of women with premature rupture of membranes detection maybe provide evidence for differential diagnosing chorioamnionitis.
|
|
|
|
|
|
|
|
|
