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| Changes of blood lipid level of pregnant women with gestational diabetes mellitus and its influence on pregnancy outcomes |
| Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University (Nanjing Maternal and Child Health Care Hospital), Jiangsu Province, 210000 |
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Abstract Objective: To understand the changes of blood lipid level of pregnant women with gestational diabetes mellitus (GDM) during pregnancy, and to analyze its influence on their pregnancy outcomes. Methods: The clinical data of 150 pregnant women with GDM (in observation group) and 150 healthy pregnant women (in control group) were analyzed retrospectively. The blood lipid index of women in the two groups was detected during the first trimester, the second trimester, and the third trimester of pregnancy. The pregnancy outcomes of women were compared between the two groups. The influence of serum lipid levels of women during the second trimester and third trimester of pregnancy on their pregnancy outcomes was analyzed. Results: There were no significant different in the blood lipids levels of women during the first trimester of pregnancy between the two groups (P>0.05). During the second trimester and the third trimester of pregnancy, the levels of TC, TG and ApoB of women in the observation group were significant higher than those of women in the control group, but the HDL-C level of women in the observation group was significant lower (P<0.05). There was no significant different in the ApoA1 level of women between the two groups (P>0.05). The levels of LDL-C of women in the observation group during the second and third trimester of pregnancy were significant lower than those of women in the control group (P<0.05). The incidences of premature delivery, cesarean section, premature rupture of membranes, macrosomia and neonatal hypoglycemia of women in the observation group were significant higher than those of women in the control group (P<0.05), while the incidence of neonatal asphyxia in the two groups had no significant difference (P>0.05). The detection rate of dyslipidemia of women during the first trimester of pregnancy had no significant difference between the two groups (P>0.05). The detection rate of dyslipidemia of women in the observation group during the second trimester and the third trimester of pregnancy was 70.7% and 80.7%, which were significant higher than those (53.3% and 58.0%) of women in the control group (P<0.05). In the observation group, the incidence of premature delivery, cesarean section, premature rupture of membranes, macrosomia and neonatal hypoglycemia of women with abnormal blood lipids level during the second and third trimester of pregnancy were significant higher than those of women with normal blood lipids level (P<0.05). Conclusion: The serum lipid level of pregnant women with GDM has a significant upward trend during pregnancy. The risk of hyperlipidemia increases during the third trimester of pregnancy, which will improve the risk of adverse pregnancy outcomes.
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