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| The value of serum PLGF, lactate dehydrogenase and uE3 levels for predicting placental abruption of pregnant women with late-onset preeclampsia |
| Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Hubei Province, 430015 |
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Abstract Objective: To analyze the value of serum placental growth factor (PLGF), lactate dehydrogenase, and free estriol (uE3) levels for predicting placental abruption of pregnant women with late-onset preeclampsia. Methods: The clinical data of 265 pregnant with late-onset preeclampsia were analyzed retrospectively, and all included women were followed up to delivery, which included 47 women with placental abruption occurred in group A and 218 women without placental abruption in group B. The clinical data and serum indexes of women were compared between the two groups. Logistic regression was used to analyze the risk factors of placental abruption of pregnant women with preeclampsia. The ROC curve was used to evaluate the value of the serum indexes for diagnosing placental abruption of pregnant women with preeclampsia. Results: The average gestational weeks when delivery, serum PLGF and uE3 levels of women in group A were significant lower than those of women in group B, but the serum creatinine and lactate dehydrogenase levels, the proportions of childbirth history and oligohydramnios of women in group A were significant higher (P<0.05). Logistics multivariate analysis showed that the levels of PLGF, lactate dehydrogenase and uE3, childbirth history, and oligohydramnios were independent risk factors of placental abruption of women with preeclampsia (P<0.05). The area under the ROC of serum PLGF level combined with lactate dehydrogenase level and uE3 level was significant greater than that of serum PLGF level, lactate dehydrogenase level, or uE3 level alone (P=0.019, 0.002, 0.001). The sensitivity and the specificity of serum PLGF level combined with lactate dehydrogenase level and uE3 level were significant better than that of serum PLGF level, lactate dehydrogenase level, or uE3 level alone (P<0.05). Conclusion: The levels of serum PLGF, lactate dehydrogenase, and uE3 have certain value predicting placental abruption of pregnant women with late-onset preeclampsia. The serum PLGF level combined with lactate dehydrogenase level and uE3 level can improve the diagnostic efficiency.
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