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Abstract Objective: To study the analgesic effect of flurbiprofen axetil combined with fentanyl citrate in missed abortion. Methods: 160 women with missed abortion were selected and were divided into observation group and control group by random number table method from August 2018 to August 2019 (80 cases in each group). All included women in the two groups were treated with painless abortion. The women in the control group were anesthetized by fentanyl citrate combined with propofol before operation, and the women in the observation group were treated by flurbiprofen except to fentanyl citrate combined with propofol. After abortion, the visual analogue scale (VAS) of women 6, 12, 24 and 36 hours after operation, the perioperative mean arterial blood pressure (MAP), heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), operation time, recovery time, and propofol dosage of women were compared between the two groups. The incidence of adverse reactions during anesthesia of women in both groups was counted. Results: The VAS score of women in the observation group at different time points after abortion was significant lower than that of the women in the control group (P<0.05). There were no different in the values of MAP, HR, SBP, and DBP of all women before and after abortion, and there were also no different in the values of MAP, HR, SBP, and DBP of women between the two groups (P>0.05). The postoperative wake time and the dosage of propofol of women in the observation group were 3.53±1.61min and 2.21±1.27 mg/kg respectively, which were significant less than those of women in the control group, but the overall incidence of adverse reactions of women in the observation group was 5.0%, which was significant lower than that (16.3%) of women in the control group (P<0.05). Conclusion: Flurbiprofen axetil combined with fentanyl citrate used in missed abortion can achieve better analgesic effect, which can reduce the dosage using of propofol, shorten the recovery time after operation, and reduce the incidence of adverse drug reactions.
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