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| The clinical efficacy of GnRH-a combined with minimally invasive surgery for treating infertility patients with endometriosis and its influence on their ovarian function and pregnancy outcomes |
| North Campus of Ruijin Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai,201800 |
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Abstract Objective: To investigate the clinical efficacy of gonadotropin releasing hormone agonist（GnRH-a) combined with minimally invasive surgery for treating infertility patients with endometriosis. Methods: 92 infertility patients with endometriosis were selected and were divided into observation group（n=47) and control group（n=45) from February 2016 to June 2017. The patients in the observation group was given GnRH0a combined with minimally invasive surgery, while the patients in the control group were given minimally invasive surgery only. The curative effect and pregnancy situation of patients in the two groups after treatment were observed, and the levels of ovarian function and inflammatory factors of patients in the two groups before and after treatment were detected. Results: One month after treatment, the curative effect of patients in the observation group was 91.5%, which was significant higher than that（80.0%) of patients in the control group. The levels of estradiol（E2), progesterone（P), CRP, IL-6 and TNF-of patients in the observation group were 40.02±11.10 ng/L, 1.72±0.32 nmol/L, 20.01±2.88 ng/L, 13.30±1.82 mg/L and 52.20±6.60 mg/L, respectively, which were significant lower than those of patients in the control group（P<0.05), but the levels of luteinizing hormone（LH) and follicle-stimulating hormone（FSH) of patients in the observation group were 17.72±3.22 IU/L and 28.10±3.32 IU/L, which were significantly higher than those of patients in the control group（P<0.05). 2 years after treatment, the pregnancy rate of patients in the observation group was 46.8%, which was significant higher than that of patients in the control group, while the recurrence rate of patients in the observation group was 12.8%, which was significant lower than that of patients in the control group（P<0.05). Conclusion: GnRH-a combined with minimally invasive surgery for treating infertility patients with endometriosis has better clinical efficacy, which can significantly improve their ovarian function, pregnancy outcomes and inflammatory cytokines.
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