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| The expressions of serum IL-1Ra and MMP-9 of women with polycystic ovary syndrome |
| Huanggang Central Hospital,Hubei Province, 438000 |
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Abstract Objective: To explore the significance of the expressions of serum Interleukin-1 Receptor Antagonist (L-1Ra) and matrix Metalloproteinase-9 (MMP-9) of women with polycystic ovary syndrome, and to study the relationship between the serum IL-1Ra and MMP-9 expression of women and their sex hormones levels. Methods: 200 women with polycystic ovary syndrome were selected in observation group from January 2013 to October 2018, and 200 healthy women were selected in control group during the same period. The levels of sex hormones, serum IL-1Ra and MMP-9 of women were compared between the two groups, and the relationship between levels of serum IL-1Ra, MMP-9 of women and their sex hormones levels was analyzed. Results: There were no significant different in levels of follicle stimulating hormone (FSH), estradiol (E2), progesterone (P) and prolactin (PRL) of women between the two groups(P＞0.05), but the levels of testosterone (T), luteinizing hormone (LH), LH/FSH, IL-1Ra and MMP-9 of women in the observation group were significant higher than those of women in the control group (P<0.05). The Pearson correlation analysis showed that the levels of serum IL-1Ra and MMP-9 had no significant correlated with the FSH level (P>0.05), and the serum IL1Ra and MMP-9 levels were positively correlated with the T level (r=0.907, 0.866, P<0.05), and were also positively correlated with the LH level (r=0.901, 0.875, P<0.05). Conclusion: The serum IL-1Ra and MMP-9 levels of women with polycystic ovary syndrome increased significantly, which have positively correlated with T and LH levels.
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