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| Relationship between the weight gain of women in different gestational weeks and their gestational diabetes mellitus occurance |
| Qingdao Municipal Hospital of Obstetrics, Shandong Province, 266000 |
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Abstract Objective: To analyze the relationship between the weight gain of women in different gestational weeks and their gestational diabetes mellitus (GDM) occurance. Methods: 752 pregnant women were enrolled in this prospective cohort study from January 2015 to January 2018. The women's weight before pregnancy, and during the first, second and third trimester of pregnancy was recorded. The weight gain of all women in different gestational weeks was calculated. The GDM incidence of women during different gestational weeks was compared among group A (women with insufficient weight gain), group B (women with normal weight gain), and group C (women with excessive weight gain). Logistic regression analysis was used to explore the relationship between gestational weight gain of women and GDM occurance. Results: In the 752 pregnant women, 131 (17.4%) women with GDM were detected. During the first trimester of pregnancy, the GDM incidence of women in group C was significant higher than that of women in group A or group B (P<0.05). During pregnancy, the GDM incidence of women in group A was the highest, but the GDM incidence of women in group C was the lowest (P<0.05). Based on normal weight gain during pregnancy as the reference category of independent variables, Logistic regression analysis showed that after adjusting the confounding factors, the risk of GDM occurance of women with excessive weight gain during the first trimester of pregnancy was 2.21, the risk of GDM occurance of women with excessive weight gain during the third trimester of pregnancy was 0.52, and the risk of GDM occurance of women with insufficient weight gain during pregnancy was 2.17 (P<0.05). Conclusion: Excessive weight gain of women during the third trimester of pregnancy and insufficient weight gain of women during pregnancy can increase the risk of GDM occurance. However, the risk of GDM occurance of women with excessive weight gain during the third trimester of pregnancy decreases, which specific mechanism needs to be further explored.
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