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| Effect of preoperative administration of parecoxib sodium on stress response and serum miR-150 and miR-155 expression levels of women after laparoscopic hysterectomy |
| Jiangsu Shengze Hospital(Shengze Branch of Jiangsu People's Hospital), Jiangsu Province, 215228 |
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Abstract Objective: To investigate the effects of preoperative administration of parecoxib sodium on stress response and expression levels of serum microRNA (miRNA) miR-150 and miR-155 of women after laparoscopic hysterectomy. Methods: 86 women who wanted laparoscopic hysterectomy were enrolled and were divided into study group and control group (43 cases in each group) by randomized digital table from November 2017 to December 2018. After anesthesia, the women in the study group were given intravenous injection of 40 mg of parecoxib sodium 30 minutes before surgery and were also given fentanyl citrate at a dose of 1.0 μg/kg 30 minutes before the end of surgery. The women in the control group were given intravenous injection of 40 mg of parecoxib sodium and fentanyl citrate at a dose of 1.0 μg/kg 30 minutes before the end of surgery. The pain visual (VAS) scores at different time point after surgery and the clinical efficacy of women were observed and compared between the two groups. The serum levels of interleukin-6 (IL-6) and cortisol (COR) before operation (T0), incision (T1) and at the time of extubation (T2) of women were compared between the two groups. The serum miR-150 and miR-155 levels at different time point of women after surgery were measured, and their correlation with pain degree was analyzed. The safety of women in both groups were recorded. Results: There were no significant different in the values of DBP, SBP and HR, and duration of surgery, recovery and extubation time of women between the two groups (P>0.05). The pain VAS scores of women at 4, 8, 12, and 24 h of women in the study group were significant lower than those of women in the control group, but the effective rate of women in the study group was significant higher (P<0.05). At the time of T1 and T2, the levels of COR and IL-6 of women in the two groups had increased significantly, but which of women in the study group were significant lower than those of women in the control group (P<0.05). The serum miR-150 level at 4, 8, 12, and 24 h after surgery of women in the both groups had increased significantly, but the level of serum miR-155 had decreased significantly, and the changes degree of the levels of serum miR-150 and miR-155 of women in the study group were significant less than those of women in the control group (P<0.05). The pain degree of women in the two groups was negatively correlated with the serum miR-150 level (r=-0.852, P=0.002), and was positively correlated with the serum miR-155 level (r=0.846, P=0.004). Conclusion: Parecoxib sodium given before laparoscopic hysterectomy has significant clinical effect, which can significantly alleviate postoperative stress response of women, and can reduce their serum miR-150 level and increase their serum miR-155 level with good safty.
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