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Abstract Objective: To investigate the influence of medical nutrition therapy (MNT) combined with metformin on chronic non-specific inflammatory status in obese women with polycystic ovary syndrome (PCOS) and insulin resistance (IR). Methods: 90 obese women with PCOS and IR were randomly divided into observation group and control group (45 cases in each group). Except to conventional therapy on PCOS, the women in the control group received metformin treatment for 3 menstrual cycles, and the women in the observation group received MNT combined with metformin treatment for 3 menstrual cycles. The body mass index (BMI), waisttohip ratio (WHR), serum levels of sex hormones, glucose and lipid metabolism indicators, inflammation indexes of women before and after treatment were compared between the two groups. Results: After treatment, the values of BMI and WHR, and the levels of serum T, LH, LH/FSH, FINS, HOMAIR, TC, TG, LDL-C, CRP, TNF-α, IL-6, IL-17, Visfatin, and Chemerin of women in the observation group were significant lower than those of women in the control group, while the HDL-C of women in the observation group was significant higher (P<0.05). Conclusion: MNT combined with metformin for treating obese women with PCOS can reduce their values of BMI and WHR, can alleviate their chronic non-specific inflammatory state, and can improve their endocrine metabolism and reproductive function.
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