|
|
|
| The change and significances of levels of serum CTRP3, chemerin, and Apelin of infertility women with polycystic ovary syndrome |
| Qingdao Women and Children Hospital, Shandong Province, 266000 |
|
|
|
|
Abstract Objective: To investigate the change and significances of levels of serum complement-Clq TNF-related protein-3 (CTRP3), chemerin, and Apelin of infertility women with polycystic ovary syndrome (PCOS). Methods: From August 2017 to August 2018, 60 infertility women with PCOS were selected in study group, and 60 infertility women without PCOS were selected in control group. The levels of serum CTRP3, chemerin, and Apelin of women in both groups were measured and their clinical significances were analyzed. Results: The serum CTRP3 level of women in the study group was significant lower than that of women in the control group, but the levels of serum chemerin and Apelin of women in the study group were significant higher (P<0.05). The value of body mass index (BMI), and the levels of C-reactive protein (CRP), low density lipoprotein cholesterol (LDL), and insulin resistance index (HOMA-IR) of women in the study group were significant higher than those of women in the control group, but the level of serum high density lipoprotein cholesterol (HDL) of women in the study group were significant lower (P<0.05). The serum CTRP3 level was negatively correlated with the BMI value, and the levels of CRP, LDL, and HOMA-IR (P<0.05), but that was positively correlated with HDL level (P<0.05). The serum CTRP3 level was negatively correlated with the chemerin and Apelin levels (P=0.000), and the serum chemerin level was positively correlated with the Apelin level (P=0.000). In the study group, the AUC by ROC curve analysis, the sensitivity, and the specificity of serum CTRP3 level were 0.769, 68.3%, and 71.7%, respectively. The AUC, the sensitivity, and the specificity of serum chemerin level were 0.772, 68.33%, and 80.0%, respectively. And the AUC, the sensitivity, and the specificity of serum Apelin level were 0.831, 78.3%, and 85.0%, respectively. Conclusion: The serum CTRP3 level of infertility women with PCOS has decreased, but their levels of Chemerin and Apelin have increased, which is related to obesity, lipid metabolism disorder, and inflammation of women. The serum CTRP3 level is negatively correlated with the levels of chemerin and Apelin, while the chemerin level is positively correlated with Apelin level. And the changes of the levels of serum CTRP3, chemerin, and Apelin have some clinical significance for diagnosing infertility women with PCOS.
|
|
|
|
|
|
|
|
|
