Abstract Objective: To explore the effect of Wenshen huatan qieyu combined mifepristone for treating women with uterine myoma because of renal deficiency and blood stasis, and to study its influence on the value of the uterine three diameters, the volume of the myoma, and the level of estrogen sulfate transferase in endometrial tissue, and sex hormones levels of the women. Methods: 98 women with uterine myoma because of renal deficiency and blood stasis were divided into two groups from December 2015-April 2019. The women in the control group were treated by mifepristone alone, and the women in the observation group were treated by Wensen huatan qieyu combined mifepristone. The clinical effect of women in the two groups was analyzed. Results: After treatment, the value of uterine third diameter, uterine myoma volume, the level of estrogen sulfate transferase in endometrial tissue, and levels of serum progesterone(P), follicle-stimulating mature hormone (FSH), estradiol (E2), highly sensitive-C reactive protein (hs-CRP), and vascular endothelial growth factor (VEGF) of women in the observation group were 93.0±10.1mm3, 28.1±6.2mm3, 28.02±3.55%, 10.14±2.85μg/L, 20.11±3.12U/L, 155.21±29.89pmol/L, 1.39±0.79mg/L, and 132.65±26.75ng/L, respectively, which were significant less than those of women in the control group (P<0.05). The hemoglobin(Hb) level of women in the observation group was 128.36±10.01g/L, which was significant higher than that of women in the control group (P<0.05). Conclusion: Wensen huatan qieyu can improve the levels of sex hormones of women with uterine fibroids, reduce the level of estrogen sulfate transferase in endometrial tissue, decrease the levels of serum hsCRP and VEGF, and can reduce the value of three diameters and volume of uterine fibroids.
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