Abstract To analyze the cause and related risk factors of perinatal natural stillbirth. Methods:A retrospective analysis of 357 cases of perinatal stillbirth from Beijing obstetrics and gynecology hospital affiliate to capital medical university between January 2012 and December 2019 was conducted. Results: ①From 2012 to 2019, there were 115447 newborns delivered in Beijing obstetrics and gynecology Hospital and 357 stillbirths were occurred in the third trimester of pregnancy. The total incidence of stillbirths was 3.1‰, which had no statistical significant difference among different years (P>0.05). ②There were 219 cases (61.3%) of perinatal natural stillbirth, and the first reason was umbilical cord winding or twisting (32.9%). The causes of perinatal natural stillbirth were different in different gestational stages. The first reason of perinatal natural stillbirth of pregnant women with less than 32 gestational weeks was therapeutic induction, which accounted for 44.6%. After 32 gestational weeks, umbilical cord or placenta was the main reason of perinatal natural stillbirth, which accounted for 54.4%. ③ There were 15 risk factors of perinatal natural stillbirth, which included advanced age, multiple pregnancy, hypertensive disorders of pregnancy, cord entanglement or abnormal umbilical cord insertion, and placenta previa, etc. Conclusion: The causes and high risk factors of intrauterine death are numerous and complicated. A focused perinatal health plan which formulated according to the needs of different gestational weeks is the key measure to further reduce the stillbirth rate.
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