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| The value of A wave inversion of venous catheter combined with fetal nuchal translucency value for screening of fetal chromosomal aneuploidy during the first trimester pregnancy |
| 1. Xishan District Maternal and Child Health Care and Family Planning Service Center, Wuxi City, Jiangsu Province, 214000; 2. Wuxi Maternal and Child Health Care Hospital; 3. Wuxi Hongqiao Hospital |
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Abstract To investigate the value of A wave inversion of venous catheter combined with fetal nuchal translucency (NT) value for screening fetal chromosomal aneuploidy of pregnant women during the first trimester of pregnancy. Methods: From January 2016 to September 2019, 2086 pregnant women who received NT ultrasound examination during 11-13 gestational weeks were selected as the study objects, and all these women were given the examination of blood flow spectrum of fetal venous catheter and fetal NT. The diagnosis "gold standard" was based on the delivery outcomes or induction outcomes. The abnormal chromosome aneuploidy of fetus was recorded. The blood flow spectrum of fetal venous catheter and the fetal NT value by ultrasound were analyzed, and which’s efficiency for predicting fetal aneuploidy was also analyzed. Results: According to the results of delivery or induced labor, 34 cases with chromosomal aneuploidy were found in 2086 fetuses. In 41 fetuses with A wave inversion of fetal venous catheter were found by ultrasound examination, 27 (65.9%) cases with chromosomal aneuploidy were identified. In 47 fetuses with thick NT were found by ultrasound examination, 28 (59.5%) cases with chromosomal aneuploidy were identified. In 39 fetuses with thick NT and A wave inversion of fetal venous catheter were found by ultrasound examination, 31(79.5%) cases with chromosomal aneuploidy were identified. The sensitivity (79.4% or 58.8%), the specificity (99.3% or 98.7%), the accuracy (99.0% or 98.0%), the positive predictive value (65.9% or 42.6%), and the negative predictive value (99.7% or 99.3%) of A wave inversion of venous catheter or NT thickening for diagnosing fetal chromosomal aneuploidy were all significant lower that those (91.2%, 99.6%, 99.5%, 79.5%, and 99.9%, respectively) of A wave inversion of venous catheter combined with NT thickening (P<0.05). Conclusion: The results of A wave inversion of venous catheter combined with NT value of fetus detected by ultrasound during the first trimester of pregnancy for screening of chromosomal aneuploidy can significantly improve the diagnostic sensitivity, specificity and accuracy, which can provide effective evidence for clinical accurate judgment and timely treatment of fetal chromosomal abnormalities.
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