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| The relationship between the situation of vaginal group B streptococcus and TNF-α expression of pregnant women with premature rupture of membranes and their neonatal adverse outcomes |
| 1. The Second Affiliated Hospital of Xi 'an Medical University, Shaanxi Province, 710038; 2. Affiliated Hospital of Shaanxi University of Chinese Medicine |
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Abstract To explore relationship between the situation of vaginal group B streptococcus (GBS) and factor-α (TNF-α) expression of pregnant women with premature rupture of membranes and their neonatal adverse outcomes. Methods: 55 pregnant women with premature rupture of membranes were selected in observation group from February 2016 to September 2018, another 50 normal pregnant women were selected in control group during the same period. The vaginal swab specimens of women in both groups were collected, and GBS was detected by polymerase chain amplification (PCR) method and TNF-αlevel was detected by immunoturbidimetry method. The positive rates of GBS and TNF-α and neonatal delivery situation in the two groups were analyzed. Results: The positive rates of GBS and TNF-αof women in the observation group were 27.3% and 29.1%, which were significant higher than those (6.0% and 8.0%) of women in the control group (P<0.05). In the observation group，the incidences of neonatal pneumonia, neonatal asphyxia, fetal distress, and preterm birth of women with GBS positive and TNF-αpositive were significant higher than those of women with GBS negative and TNF-αnegative (P<0.05). In the 105 women, the incidences of neonatal pneumonia, neonatal asphyxia, fetal distress, and preterm birth of women with GBS positive and TNF-αpositive were significant higher than those of women with GBS negative and TNF-αnegative (P<0.05). Conclusion: The GBS and TNF-αsituation of these pregnant women have certain relation with their premature rupture of membranes occurrence, so early treatment can reduce adverse pregnancy outcomes of them in clinical practice.
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