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| Clinical efficacy of Danzhi xiaoyao tablets for treating infertile women with dysfunctional ovulatory by PCOS, and its influence on their pregnancy outcomes |
| The Third People's Hospital of Chengdu City, Sichuan Province, 610031 |
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Abstract To analyze the clinical efficacy of Danzhi xiaoyao tablets for treating infertile women with dysfunctional ovulatory by polycystic ovary syndrome (PCOS), and to study its influence on their pregnancy outcomes. Methods: The clinical data of 120 infertile women with dysfunctional ovulatory by PCOS from January 2016 to January 2019 were analyzed retrospectively. According to different treatment, these women were divided into 48 cases in the control group (women with conventional western medicine treatment) and 72 cases in the observation group (women with conventional Western medicine treatment combined with Danzhi Xiaoyao tablet). The sex hormone levels changes, ovarian function, pregnancy outcomes, and adverse reactions of women before and after treatment were compared between the two groups. Results: After treatment, the levels of sex hormones of women in the two groups had increased significantly (P<0.05), the E2 level of women in the observation group (279.86±37.89 pgl/ml) was significant higher than that (255.26±35.33 pgl/ml) of women in the control group, but the levels of T (2.33±0.87 pmol/ml), FSH (5.21±0.88 mlu/ml), and LH (11.48±1.46 mlu/ml) of women in the observation group were significant lower. After treatment, the ovarian condition of women in both groups had improved significantly (P<0.05), the number of dominant follicles and the diameter of the dominant follicles of women in the observation group were significant better than those of women in the control group. After treatment, the diameter of follicles (8.93±0.45mm) and endometrial thickness in luteal stage (12.38±0.46mm) of women in the observation group were significant higher than those of women in the control group. After treatment, the proportion of endometrium in type A (69.4%) and the pregnancy rate (55.6%) of women in the observation group were significant higher than those (31.3% and 35.4%) of women in the control group (P<0.05). There was no significant difference in the miscarriage rate of women between the two groups (P>0.05), and the total incidence of adverse reactions (2.78%) of women in the observation group had no significant different from that (2.08%) of women in the control group (P>0.05). Conclusion: Danzhi xiaoyao tablet combined with conventional western medicine for treating women with dysfunctional ovulatory by PCOS has significant clinical effect, which can increase improve their sex hormone levels, ovulation rate, and pregnancy rate with high safety.
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