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| Effect of hypothyroidism of pregnant women during the pregnancy on maternal glucolipid metabolism and the pregnancy outcomes after intervention by levothyrocine |
| Third Hospital of Xingtai city, Hebei Province, 054000 |
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Abstract To analyze the changes of glucose and lipid metabolism of pregnant women with hypothyroidism during the first and the second trimester of pregnancy, and to explore the effect of drug intervention on pregnancy outcomes. Methods: The pregnant women with hypothyroidism were collected to been divided into group A (women with hypothyroxinemia), group B (women with subclinical hypothyroidism), and group C (women with hypothyroxinemia) according to the different types of hypothyroidism, and the pregnant women with normal thyroid function were selected in group D. The indexes of glucose and lipid metabolism of women during the first and second trimester of pregnancy were compared among these four groups. The women in group A and B were given L-T4 intervention, and the pregnancy outcomes of women were compared among the four groups. Results: During the first and second trimester of pregnancy, the levels of HbA1c and TG of women had no significant different between group C and D (P>0.05), but which had significant different among other groups (P＜0.05). The TG level of women had no significant different between group A and B (P>0.05), but which had significant different among other groups (P＜0.05). There were no significant different in the levels of FBG, TCH, HDL and LDL of women among the three groups (P>0.05). During the second trimester of pregnancy, the levels of FBG, HbA1c, TG and LDL had no significant different between group C and D (P>0.05), but which had significant different between group A and B (P＜0.05). During the second trimester of pregnancy, the levels of FBG and LDL had no significant different among group B, C and D (P>0.05), but which had significant different between group A and B, between group A and C, or between group A and D (P＜0.05). TCH and HDL levels of women had no significant different among the four groups (P>0.05). The incidences of premature rupture of membranes, gestational diabetes, and premature birth of women in group C had no significant different from those of women in group D (P>0.05), but were significant higher than those of women in group A and B (P＜0.05). There were no significant different in the incidences of anemia during pregnancy, low birth weight, macrosomia, and fetal distress among the groups (P>0.05). Conclusion: The hypothyroidism and subclinical hypothyroidism during pregnancy can lead to the abnormal glucose and lipid metabolism, in which, the influence of hypothyroidism is higher. The influence of women with hypothyroidism on their glucose and lipid metabolism during the second trimester is more than that during the first trimester. The normal level of TSH by L-T4 treatment can improve the pregnancy outcomes. The hypothyroxinemia during pregnancy has no adverse effect on glucose and lipid metabolism and pregnancy outcomes.
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