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| Distribution characteristic of intestinal microflora of pregnant women with gestational diabetes mellitus and its correlation with their pregnancy outcomes |
| Tinglin Hospital of Jinshan District, Shanghai, 201505 |
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Abstract To study the characteristics of intestinal microflora distribution of pregnant women with gestational diabetes mellitus (GDM), and to analyze its correlation with their pregnancy outcomes and newborn. Methods: 160 pregnant women were enrolled and were divided in observation group (83 women with GDM) and control group (77women without GDM) from January 2017 to January 2019. The T lymphocyte subsets, inflammatory factors expression levels, intestinal flora changes, pregnancy outcomes, and the newborns situation of women were compared between the two groups. Results: The expression levels of hs-CRP, TNF-α, IL-6, and CD8 of women in the observation group were significant higher than those of women in the control group, while the expressions of IL-10 , CD3, CD4 and CD4/CD8 of women in the observation group were significant lower (P<0.05). The concentrations of enteric bacilli and saccharomycetes in fresh stool of women in the observation group were 11.02±1.02 IgN/g and 4.94±0.81 IgN/g, which were significant higher than those (8.01±0.94 IgN/g and 3.79±0.75 IgN/g) of women in the control group. The concentrations of bifidobacteria, lactobacillus, and bacteroides of women in the observation group were 6.92±0.71 IgN/g, 6.82±0.88 IgN/g, and 7.32±0.59 IgN/g, which were significant lower than those (9.21±0.78, 8.31±0.79 IgN/g, and 8.99±0.62 IgN/g) of women in the control group (all P<0.05). The rates of gestational hypertension, polyhydramnios, premature delivery, postpartum hemorrhage, and puerperal infection of women in the observation group were significant higher than those of women in the control group, and th rates of neonatal malformations, neonatal hypoglycemia, and fetal distress in the observation group were significant higher than those in the control group (P<0.05). Conclusion： The intestinal microflora distribution of pregnant women with GDM has the characteristic of probiotics decreasing and pathogenic bacteriao increasing, which leads to the abnormal inflammatory factors and decreased cellular immune function. GDM can cause serious adverse influence on pregnancy outcomes and neonates, hence it is necessary to strengthen pregnancy care and adopt relevant valid intervening measure.
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