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| Efficacy of letrozole combined with clomiphene for treating women with difficult ovulatory |
| The Second People's Hospital of Hengshui, Hebei Province, 053000 |
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Abstract To compare the efficacy of letrozole combined with clomiphene and clomiphene alone for treating women with difficult ovulatory. Methods: 146 women with ovulatory disorder were selected and divided into two groups from July 2018 to July 2019. The women in control group were treated with clomiphene alone, and the women in observation group were treated with letrozole combined with clomiphene. The clinical efficacy of women in the two groups after treatment was analyzed. Results: The endometrium thickness (9.86 ± 1.28) mm, uterine volume (5.58±0.96) ml, mature follicle diameter (25.98 ± 2.85) mm of women in the observation group were significant higher than those of women in the control group, but diestradiol (E2) level on hCG day of women in the observation group (428.12 ± 76.25 pg/ml) was significant lower than that of women in the control group (P<0.05). The levels of luteinizing hormone (LH) and testosterone(T) of women in the observation group were 10.18 ± 3.66 IU/ml and 58.01 ± 12.79 ng/dl, which had no significant different from those of women in the control group (P>0.05). The levels of connective tissue growth factor (CTGF) and tumor necrosis factor-α (TNF-α) of women in the observation group were significant lower than those of women in the control group (P<0.05), but there were no significant different in the level of serum insulinlike growth factor (IGF-1) between the two groups (P>0.05). The ovulation rate (68.5%) and pregnancy rate (49.3%) of women in the observation group were significant lower than those of women in the control group (P<0.05), but the abortion rate (2.7%) of women in the observation group had no significant different from those of women in the control group (P>0.05). Conclusion: The effect of letrozole combined with cromiprofen for treating difficult ovulation of women with PCOS is better than that of cromiprofen used alone.
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