Abstract To investigate the correlation between the levels of serum HMGB1, IL-33, IL-6, IL-10, IL-17 and TGF-βof women with unexplained recurrent spontaneous abortion (URSA) and their immune indexes. Methods: 126 pregnant women were selected and were divided in study group (66 women with URSA) and in control group (60 normal women). The changes of serum HMGB1, IL-33, IL-6, IL-10, IL-17, and TGF- βlevels of women were compared between the two groups. And their correlation was analyzed. Results: The levels of the serum HMGB, IL-6 and IL-17 of women in the study group were significant higher than those of women in the control group, but the levels of serum IL-33, IL-10 and TGF-βof women in the study group were significant lower (P＜0.05). In the study group, serum HMGB1 level was positively correlated with IL-6 and IL-17 levels, but was negatively correlated with IL-10 and TGF-β levels (P＜0.05). In the study group, serum IL-33 level was negatively correlated with IL-6 and IL-17 levels, but was positively correlated with IL-10 and TGF-βlevels (P＜0.05). Conclusion: HMGB1 expression of women with URSA during the first trimester of pregnancy is up regulation, but the level of IL-33 is down regulation, which may be involved in the occurrence of the disease by regulating the level of cytokines of Thl7 and Treg cell.
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