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| Effect of progesterone combined with modified shoutai pill for treating pregnant women with early threatened abortion because of kidney deficiency and its influence on inflammatory factors |
| 1.Jiangbei Hospital of Zhongda Hospital Affiliated to Southeast University(Nanjing Dachang Hospital),Jiangsun Province, 210043；2.Zhongda Hospital Affiliated to Southeast University |
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Abstract Objective: To investigate the effect of progesterone combined with modified shoutai pill for treating pregnant women with early threatened abortion (TA) because of kidney deficiency, and to study its influence on inflammatory factors. Methods: The clinical data of 98 women with TA from January 2015 to August 2018 were retrospective analyzed. Among them, 54 women in the study group were treated by progesterone and HCG combined with modified shoutai pill, and 44 women in the control group were treated by progesterone and HCG. The TCM syndrome scores, levels of sex hormones and inflammatory cytokines, and pregnancy outcomes of women were compared between the two groups. Results: After treatment, the TCM syndrome scores of all women in the two groups had significantly decreased, and the scores of vaginal bleeding (0.29±0.21 points), bleeding color (0.21±0.27points), lumbar and knee tenderness (0.22±0.27points), and swelling and lower abdominal pain scores (0.26±0.22 points), and bleeding time (0.20±0.15) of women in the study group were all signifficent lower than those of women in the control group (P<0.05). The levels of E2,β-hCG , and P of all women in the two groups had significantly increased after treatment, and the levels of E2 (1087.26±253.23 pg/ml), β-hCG(102633.32±6723.72mIU/ml), and P (80.93±8.24pg/ml) of women in the study group were all signifficent higher than those of women in the control group (P<0.05). After treatment, the levels of IL-2 (3.45±0.15ng/ml), IL-4 (0.25±0.05ng/ml), and INF-r (1.13±0.11ng/ml) of women in the study group were signifficent better than those of women in the control group (P<0.05). The success rate of spuc treatment of women in the study group was 94.4%, which was significant higher than that (84.1%) of women in the control group (P<0.05), and the incidence of preterm labor of women in the study group was 0.0%, which was significant lower than that (13.5%) of women in the control group (P<0.05). Conclusion: Modified shoutai pill combined with progesterone and HCG for treating pregnant women with early threatened abortion can achieve good spuc treatment efficacy by alleviating clinical symptoms, promoting sex hormone level, and correcting the pathological shift of inflammatory factors of women.
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