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| Clinical efficacy of ditroxyprogesterone tablets combined with choriotropin for treating women with unexplained recurrent abortion and its influence on their T lymphocyte cell and inflammatory factor levels |
| 1.Dandong Women's and Children's Hospital, Liaoning Province, 11800；2.Shenyang Gynecology and Infant Hospital Liaoning Province |
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Abstract Objective: To explore the clinical efficacy of ditroxyprogesterone tablets combined with choriotropin for treating women with unexplained recurrent abortion (URSA), and to study its influence on T lymphocyte cell and inflammatory factor levels of women. Methods: 100 women with URSA were enrolled in this study and divided into group A and Group B (50 cases in each group) according to simple randomized method from June 2017 to November 2018. The women in group A were treated with ditroxyprogesterone tablets combined with chorionic gonadotropin, and the women in Group B were treated with luteinone combined with chorionic gonadotropin. The serum levels of (IL)-4, IL-6, IL-10, IL-17, INF- γ, TNF-α, highly sensitive C-reactive protein (hs-CRP), CD4 regulatory T cell Treg (Treg/CD4, CD4 T helper cell Th17 (Th17/CD4), helper T cell 17 / regulatory T cell (Th17/ Treg) of women during 8 and 12 gestational weeks were compared between the two groups. The pregnancy outcomes of women in the two groups were counted. Results: The levels of IL-4,IL-10,Treg CD4 of women in both groups during 12 gestational weeks were significant higher than those of women during 8 gestational weeks, but the levels of IL-6,IL-17,INF- γ, TNF- α, hs-CRP,Th17/CD4, and Th17/ Treg of women in the two groups during 12 gestational weeks were significant lower than those of women during 8 gestational weeks, and the change degree of those of women in group A was significant more than those of women in group B (P<0.05). The rate of abortion of women in group A was 17.0%, which was significant lower than that (40.9%) of women in group B,and the rate of full term delivery of women in group A 63.8%, which was significant lower than that (31.8%) of women in group B (P<0.05). Conclusion: The combination of ditroxyprogesterone tablets and choriotropin for treating women with URSA is effective, which can regulate the level of T lymphocyte factor and inflammatory factor, can reduce the risk of abortion, and can mprove the success rate of pregnancy preservation by promoting the balance of mother-fetus immunity.
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