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| Clinical efficacy of levonorgestrel intrauterine releaseing system combined with GnRH-a for postoperation adjuvant therapy in women with severe endometriosis |
| Integrated Chinese and Western Medicine Hospital of Wuxi, Jiangsu Province, 214000 |
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Abstract Objective: To investigate the clinical efficacy of levonorgestrel release intrauterine system (LNG-IUS) combined with gonadotropin-releasing hormone analogue (GnRH-a) for adjuvant therapy of women with severe endometriosis (EMT) after operation, and to anlyze its influence on sex hormone levels of women. Methods: 100 women with severe EMT who had undergone surgery from January to December 2018 were randomly divided into observation group and control group. 50 women in the control group were treated by GnRH-a only, and 50 women in the observation group were treated by LNG-IUS combined with GnRH-a. The clinical efficacy, sex hormone levels, and ovarian reserve function of women before surgery (T0), postoperative 6 months (T1), 12 months (T2) were compared betweent the two groups. Result: The dysmenorrheal degree, sexual pain score, and the serum CA125 level of women in the two groups at T1 and T2 had significantly decreased after operation (P<0.05). The dysmenorrhea score of women in the observation group at T2 was 1.66±1.09 point, which was significant lower than that (2.06±1.33 points) of women in the observation group at T1 and that (2.04±1.23 points) of women in the control group at T2. The serum CA125 level of women in the observation group at T2 was 9.82±1.84 mg/L, which was significant lower than that(12.42±2.62 mg/L) of women in the observation group at T1 (P<0.05). The levels of FSH, LH and E2 of women in both groups had significantly decreased after operation, and the serum E2 level of women in the observation group at T2 was significant higher than that of women in the control group (P<0.05).The number of ovarian sinus follicle and PSV of women in both groups had significantly decreased after operation, and that of women at T2 were significant higher compared to that at T1 (P<0.05), but there was no significant different in the number of ovarian sinus follicle and PSV of women between the two groups (P>0.05). Conclusion: LNGIUS combined with GnRH-a for adjuvant therapy of women with severe EMT can increase clinical efficacy, improve sex hormone levels, and has no adverse effect on ovarian reserve function recovery.
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