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Abstract Objective: To explore the reference range of thyroid function indexes of pregnant women during different gestational weeks, and to provide reliable evidence for diagnosing thyroid diseaseof women during pregnancy. Methods: The pregnant women during different gestational weeks who firstly for thyroid function testing were selected as the study objects, which included 220 women during the first trimester pregnancy (in 1-12 gestational weeks) in group A, 220 women during the second trimester pregnancy (in 13-27 gestational weeks) in group B, 220 women during the third trimester pregnancy (in 28-40 gestational weeks) in group C, and 220 women without pregnancy in group D. The levels of thyrotrophin (TSH) and free thyroxine (FT4) of all women were detected. Results: The median level of TSH of women in group A, B, and C were 0.02-4.27mIU/L, 0.085.07mIU/L, and 0.48-5.08mIU/L, respectively. And the median level of FT4 of women in group A, B, and C were 12.08-24.80pmol/, 9.76-17.82pmol/L, and 9.27-16.10pmol/L, respectively. Of women in group A, the TSH level was the lowest, but FT4 level was the highest (P<0.05). Conclusion: The establishment of range of thyroid function indexes of pregnant women during different gestational weeks is beneficial to the screening and diagnosis of thyroid diseases of pregnant women.
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