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| A cohort study of the relationship between IUD use and secondary infertility of women |
| Jiangsu Institute of Planned Parenthood Research, NPFPC Contraceptives Adverse Reaction Surveillance Center, Nanjing, Jiangsu province, 210036 |
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Abstract Objective: To study the relationship between intrauterine device (IUD) use and secondary infertility of women. Methods：IUD cohort and condom cohort were established according to contraceptives used by women after the first child delivery based on the National Free Prenatal Health Examination Project. The women of secondary infertility in the two groups were followed up. The influencing factors of secondary infertility were analyzed. Results：The infertility rate of women in IUD group and condom group was 18.7% and 18.1%, respectively. The infertility rates of women with IUD usage less than 1 year, 1-years, and ≥5 years were 18.6%, 19.8% and 16.9%, respectively. The infertility rates of women with IUD termination for non-medical reasons and medical reasons were 19.6% and 25.0%, respectively. No statistical correlation was found between IUD usage time or termination reason with the occurrence of secondary infertility. Multivariate logistic regression analysis showed that rate of secondary infertility of women in IUD group was 0.95 times of that of women in condom group (P>0.05). It was also found that male overweight and women in south area of Jiangsu province were the protective factors for infertility (P<0.05), but female age, female obesity, female anemia, and illness of the first child were the risk factors for infertility (P<0.05). Conclusion：IUD usage doesn’t increase the risk of secondary infertility.
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