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| The value of colposcopy biopsy combined with P16 and OLFM4 for diagnosing women with cervical intraepithelial neoplasia |
| Hubei Provincial Maternal and Child Health Care Hospital, Wuhan, Hubei Province, 430070 |
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Abstract Objective: To observe the value of colposcopy biopsy combined with P16 and OLFM4 for diagnosing women with cervical intraepithelial neoplasia (CIN). Methods: From April 2017 to April 2019, 240 patients with CIN who underwent colposcopy biopsy were selected into study group, which included 98 cases with CIN I, 82 cases with CIN II and 60 cases with CIN III based on the pathological diagnostic results. Another 60 patients with cervical benign lesion were selected into control group. The results of colposcopy biopsy of all patients were observed. The expressions of P16 and OLFM4 were detected by immunohistochemistry. Results: The coincidence rates of CIN I, CIN II and CIN III diagnosis by colposcopy biopsy were 91.7%, 90.2%, and 96.7%. The positive expression rates of P16 and OLFM4 of women in the control group were significant lower than those of women in the control group (P<0.05). The positive expression of P16 and OLFM4 was the lowest in the patients with CIN I and was the highest in the patients with CIN III (P<0.05). Conclusion: Colposcopy biopsy combined with the expression of P16 and OLFM4 can increase the detection rate of CIN. Excessive expressions of P16 and OLFM4 are closely related to the occurrence, development and prognosis of CIN.
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