|
|
|
| The influence of general anesthesia combined with epidural anesthesia in laparoscopic assisted vaginal hysterectomy of women with uterine benign disease on their hemodynamics and serum D-D, PAI 1 and tPA levels |
| The Second People's Hospital of Xining, Qinghai Province, 810003 |
|
|
|
|
Abstract Objective: To investigate the influence of general anesthesia combined with epidural anesthesia in laparoscopic assisted vaginal hysterectomy of women with uterine benign disease on their hemodynamics and levels of serum tissue type plasminogen activator (tPA), plasminogen activator inhibitor 1 (PAI 1), D dimer (D-D). Methods: From May 2014 to September 2016, 72 women with uterine benign disease were randomly divided into control group and study group (36 cases in each group). The women in the control group were treated by intravenous anesthesia combined with general anesthesia, and the women in the study group received epidural anesthesia combined with general anesthesia. The amount of anesthesia drug for maintaining anesthesia, the recovery situation after anesthesia, the hemodynamic parameters［Heart rate (HR), mean arterial pressure (MAP)］and serum fibrinolytic function index (t PA, PAI 1, D-D) during different time periods before anesthesia (T1), 5 min after anesthesia (T2), immediately after extubation (T3)］, and the adverse reaction rate of women were compared between the two groups. Results: The amount of propofol and vecuronium used for women in the study group during operation was significant less than that for women in the control group (P<0.05). The recovery time, tracheal tube withdrawal time, and time of spontaneous breathing recovery of women in the study group were significant less than those of women in the control group (P<0.05). There were no significant different in HR, MAP and the levels of serum tPA, PAI 1 and D-D of women between the two groups at T1 (P>0.05), but HR, MAP, and the levels of serum tPA, PAI 1 and D-D of women in the study group were significant lower than those of women in the control group at T2 and T3 (P<0.05). The rates of tachycardia, vomiting and nausea, and restless of women in the study group were 13.9%, 16.7%, and 8.3%, respectively, which were significant lower than those (36.1%, 38.9%, and 27.8%, respectively) of women in the control group (P<0.05). Conclusion: The general anesthesia combined with epidural anesthesia used in laparoscopic assisted vaginal hysterectomy of women with uterine benign disease can effectively reduce the amount of anesthesia drugs, can stabilize intraoperative hemodynamic, has less influence on the fibrinolytic function of women, the incidence of adverse reactions is low, and the recovery after anesthesia is quick, so its safety is high.
|
|
|
|
|
|
| Cite this article: |
|
SU Gengsheng. The influence of general anesthesia combined with epidural anesthesia in laparoscopic assisted vaginal hysterectomy of women with uterine benign disease on their hemodynamics and serum D-D, PAI 1 and tPA levels[J]. 中国计划生育学杂志, 2019, 27(9): 1166-.
|
|
|
|
| URL: |
| https://www.zgjhsyx.com/EN/ OR https://www.zgjhsyx.com/EN/Y2019/V27/I9/1166 |
|
|
|
