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Abstract Objective: To explore the curative efficacy of traditional Chinese medicine formula (Ziyin buseng) for treating women with polycystic ovary syndrome (PCOS), and to study its influence on the follicular growth of women. Methods: 68 women with PCOS were selected and were divided into observation group (n=35) and control group (n=33) by random number table from July 2015 to July 2017. The women in the observation group were treated by traditional Chinese medicine formula (Ziyin buseng), while the women in the control group were treated by clomiphene. The clinical curative effect, the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), estradiol (E2), insulin (INS), vascular endothelial growth factor (VEGF), endothelial inhibition (ES), follicular fluid catalase (CAT), glutathione peroxidase (GPx), glutamic acid cysteine ligase (Gcl c), total antioxidant capacity (TAC), and superoxide dismutase (SOD), and ovarian stroma pulsation index (PI), resistance index (RI), systolic peak flow velocity (PSV) and systolic/diastolic peak flow velocity at the end of blood flow velocity (S/D) of women were compared between the two groups. Results: After treatment, the total effective rate of women (94.3%) in the observation group was significant higher than that (72.7%) of women in the control group. Serum levels of VEGF, ES, PI, RI, PSV, S/D, FSH, LH, T, E2 and INS of all women in the two groups had significantly decreased, and those of women in the observation group were significant lower than those of women in the control group (P<0.05). The levels of TAC, SOD, CAT, GPx and Gc lc in follicular fluid of all women had significantly increased, and those of women in the observation group were significant higher than those of women in the control group (P<0.05). Conclusion: Traditional Chinese medicine formula (Ziyin buseng) for treating women with PCOS and Traditional Chinese medicine Shenyangxu has good efficacy, which can effectively promote the follicular growth and improve the hemodynamic situation of the ovarian interstitium of women.
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