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Abstract Objective: To investigate the blood trace elements levels of pregnancy women with different age during the first and second trimester pregnancy, and to provide evidences for the reasonable and safe supplementation of trace elements of pregnant women. Methods: 6620 health pregnant women aged 20-39 years were divided into group A (2530 cases during the first trimester pregnancy ) and group B (4090 cases during the second trimester pregnancy), and other 200 health women without pregnancy were selected in group C. The blood copper, zinc, calcium, magnesium and iron of all included women were tested. Results: There were no significant different in the blood calcium and magnesium between pregnant women and non-pregnant women (P>0.05), but the blood copper level of women in group A and B was significantly higher than that of women in group C, and the levels of blood zinc and iron in group A and B were significant lower than those of women in group C (P<0.05). In group A and B, the blood copper level of women with 26-36 years old and ≥36 years old were significant higher than that of women with ≤25 years old (P<0.05). In group B, the blood iron level of women with 26-36 years old and ≥36 years old were significant lower than that of women with ≤25 years old (P<0.05). The rate of low iron level of women in group A and B was 16.1% and 27.8%, respectively, which was significant different from that of women in group C (P<0.01). The rate of low zinc level of women in group A and B was 5.8% and 9.6%, respectively, which was significant different from that of women in group C (P<0.01). The rate of low calcium level of women in group A and B was 4.97% and 4.96%, respectively, which was significant different from that of women in group C (P<0.05). Conclusion: In order to meet the needs of mothers and fetuses, it should be supplemented trace elements according to the characteristics of different trace elements levels of pregnant women in different ages during different pregnant stage.
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