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| Combined detection of serum PRL, beta-HCG and CA125 levels to predict the outcomes of women with threatened abortion |
| Beijing Chaoyang Emergency Rescue Center, Beijing,100000 |
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Abstract Objective: To investigate the predictive value of combined detection of serum prolactin (PRL), beta-human chorionic gonadotropin (β-HCG), and serum glycoprotein 125 (CA125) levels for the outcomes of women with threatened abortion after spuc treatment. Methods: 136 pregnant women with threatened abortion were divided into group A (110 women with continuous pregnancy) and group B (26 women with inevitable abortion), and other 80 normal pregnant women were selected in group C. All included women were received serum PRL, β-HCG and CA125 levels detected, and the predictive value of combined detection of serum PRL, β-HCG and CA125 for the outcomes of women with threatened abortion after spuc treatment were analyzed. Results: The serum levels of PRL and β-HCG of women in group A and B were significant lower than those of women in group C, and those of women in group A were significant lower than those of women in group B, but the level of CA125 of women in group A and B was significant higher than that of women in group C (P<0.05). The levels of PRL and-HCG of women in 5, 7 and 9 gestational weeks in group A were significant lower than those of women in group B, but the level of CA125 of women in group A and B was still significant higher than that of women in group C (P<0.05). The sensitivity, specificity and accuracy of combined detection of PRL, β-HCG and CA125 levels for diagnosing inevitable abortion of women with threatened abortion after spuc treatment were 89.2%, 93.4% and 89.9%, respectively, which were significant higher than those of level detection of PRL, beta-HCG or CA125 alone (P<0.05). Conclusion: Combined detection of serum PRL, β-HCG and CA125 levels of women with threatened abortion during the first trimester pregnancy has high predictive value for inevitable abortion.
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