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Abstract Objective: To evaluate the effect of volume therapy based on stroke volume variation(SVV) of patients in gynecologic laparoscopic surgery. Methods: 53 patients with gynecological tumors (ASA I-III, 18-65 years old) who had undergone gynecologic laparoscopic surgery were included and randomly divided into group A (fluid therapy based on SVV) and group B (conventional fluid therapy). The blood pressure (BP) and central venous pressure (CVP) of all patients were monitored through radial artery puncture and internal jugular vein puncture under local anesthesia. The Flotrac/Vigileo system was used to obtain SVV value and cardiac index (CI)．The patients in group A had received fluid therapy based on values of SVV, MAP, and CI, and CI≥2.6L/min/m2 and SVV 8-12 of patients were the treatment goal indexes. The patients in group B had received conventional fluid therapy based on"4-2-1" rule．The liquid flow in and out during surgery, crystalloid requirements, the changes of MAP, HR and CVP of all women at the onset of the monitoring (T1), the induction time after anesthesia (T2), the beginning of surgery (T3), 1 hour after surgery (T4) and the end of the surgery (T5) were recorded．The values of MAP, HR and the concentration of serum lactate of all women when transferred to ward and 24 hours after operation were also recorded. The incidence of postoperative complications and time of stay in hospital of patients in the two groups were observed. Results: The volume of colloid fluid used and values of CI and CVP at T3 and T4 of women in group A were significant higher than that of women in group B, but the volumes of crystal fluid used and urinary output, the concentration of serum lactate, and the incidence of adverse reaction of women in group A were significant lower (P<0.05)．Conclusion: The volume therapy based on SVV can optimize the cardiac preload of patients who undergoing gynecologic laparoscopic surgery, improve their cardiac output, guarantees their perfusion of microcirculation, reduce the incidence of adverse reactions, and shorten time of hospitalization, which is more effective than conventional fluid therapy．
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