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| The correlation between the estradiol level of women with estimated normal ovarian response on day 5 after controlled ovarian hyperstimulation and their actual ovarian response |
| 1. Shunyi District Maternal and Child Health Care Hospital, Beijing, 101320；2. Beijing Chaoyang Hospital, Capital Medical University |
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Abstract Objective: To explore the correlation between the estradiol (E2) level of women with estimated normal ovarian response on day 5 after controlled ovarian hyperstimulation (COH) and their actual ovarian response. Method: Methods: The data of women with estimated normal ovarian response who wanted in vitro fertilization and embryo transfer (IVF-ET) between January 2015 and September 2017 were retrospectively analyzed. The included women had accepted GnRH agonist long protocol as for COH, and their E2 level on the 5 day after COH was detected. All the women were divided into three groups based on the value of E2 level, which included women with E2 level equal to or over 1460pmol/L were in group A, women with E2 level from 730pmol/L to 1460pmol/L were in Group B, and women with E2 level equal to or less than 730pmol/L were in group C. The risk rate of poor or high ovarian response ovarian response of women was compared among the three groups. Results: The rate of high ovary response of women in group A (35.6%) and B was significant higher than that of women in group C, but there was no statistical significance different among the three groups (P>0.05). As the E2 level increased on the 5 day after COH, the rate (3.6%, 5.7%, and 16.9%, respectively) of ovarian hyper-stimulation syndrome (OHSS) increased gradually, and there was statistical significance different in the rate of OHSS among the three groups (P<0.05). The rate of poor ovary response of women in group C was highest (53%), and there was statistical significance different in the rate of poor ovary response among the three groups (P>0.05). Conclusion: For women who were estimated having normal ovarian response, E2 level on the 5 day of COH can be as a good predictor for identify the actual ovarian response.
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