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Abstract Objective: To analyze the reference value of serum placental growth factor (PLGF) level for prenatal screening of Down's syndrome (DS) of pregnant women during the first trimester pregnancy. Methods: From October 2017 to October 2018, 1806 pregnant women who were been screened DS during the first trimester pregnancy were selected as subjects, which included 48 pregnant women with high risk of DS were in the study group, and the other 1758 pregnant women were in the control group. The levels of serum PLGF, AFP, β-hCG, and PAPP-A of women in the two groups were examined and compared, and the diagnostic sensitivities of these indicator were compared. Results: The PLGF level of women (68.25±4.58 pg/mL) in the study group was significant lower than that (109.58±8.69 pg/mL) of women in the control group (P<0.05), but there were no significant differences in the levels of AFP, β-hCG and PAPP-A of women between the two groups (P>0.05). The AOC area of level of PLGF combined with levels of AFP, β-hCG, and PAPP-A for diagnosing women with high risk of DS during the first trimester pregnancy was significant higher than that of PLGF level, AFP level, β-hCG level, or PAPP-A level only (P<0.05). Conclusion: The maternal serum PLGF level is a sensitive indicator for DS screening during the first trimester pregnancy, it is worthy of clinical used for early screening DS by serum PLGF level combined with other conventional serological markers.
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