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Abstract Objective: To investigate the levels of serum 25-hydroxy-vitamin D ［25(OH) D］ of pregnant women in different gestational weeks, and to explore its correlation with infant growth and development. Methods: 989 pregnant women who regularly received prenatal care and hospitalized for delivery were selected and divided into three groups according to different gestational weeks from June 2016 to June 2017, which included group A (≤12 gestational weeks, n=182), the group B (1228 gestational weeks, n=517), and the group C (≥28 gestational weeks, n=301). The serum levels of 25(OH) D of the women in the three groups were measured, the growth and development of infants in the three groups were evaluated. Results: The average serum 25(OH)D level of all women was (35.56±11.49)nmol/L, and 78.6% of pregnant women were vitamin D lack or deficiency. Among them, the rate of vitamin D lack or deficiency of women in group A was 92.3%, which was significant lower than that of women in group B (77.9) or that (71.4%) of women in group C (P<0.05). The serum 25(OH) D levels of pregnant women in winter and spring were significant lower than those of women in summer and autumn (P<0.05). After treatment, only 37.6% of prenatal women were vitamin D lack or deficiency. There were no significant difference in birth weight, body length and head circumference of the newborns among the prenatal women with different vitamin D lack. As for 3 months infants, there were also no significant difference in birth weight, body length and head circumference weight length, head circumference (P>0.05). When the infants were 6 months old, the length and head circumference of the infants of women with the vitamin D lack during pregnancy was significant lower than that of the infants of women with the vitamin D sufficient (P<0.05). Conclusion: Vitamin D lack during pregnancy is prevalent in pregnant women, especially during early pregnancy, so it is necessary to monitor serum level of 25(OH) D of pregnant women and to take some necessary intervention measures. While the maternal vitamin D lack has limited adverse effect on infant growth and development.
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