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| A study of the mifepristone combined with misoprostol for medical abortion during the first trimester pregnancy |
| Peking University People’s Hospital, Beijing, 100044 |
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Abstract Objective: To explore the possibility of simplifying the followed up procedure after medical abortion during the first trimester pregnancy through the analysis of the uterine recovery in different followed up time after medical abortion by misoprostol combined with mifepristone. Methods: A retrospective analysis was performed on 1536 women who received mifepristone combined with misoprostol for medical abortion during the first trimester pregnancy in 2018. Results: There were 456 (29.7%) women lost followed up, and another 1080 (70.3%) women had completed followed up. The average number of gravidity and parity of women who had lost followed up were 2.6, and 0.7, respectively, which were significant different from those (2.0 and 0.5) of women who had finished followed up (P=0.000). Among the 1080 women finished followed up, 992 (91.9%) cases with completed abortion, 48 (4.4%) cases with incomplete abortion, and 40 (3.7%) cases with abortion failure. In the 992 cases with completed abortion, 911 women had received the urine pregnancy test. And in women received the urine pregnancy test, 212 (23.3%) cases were negative urine pregnancy test 2 weeks after medical abortion and 428 (70.3%) cases were negative urine pregnancy test in 3 weeks followed up, the cumulative negative rate was 70.3%. Over 4 weeks followed up, 271 women were negative pregnancy test, and the cumulative negative rate was 100%. All the women were given B ultrasonography examination in 2, 3, 4 weeks followed up, and the rates of proportion of endometrial repair of women with negative urinary pregnancy test were high, which had statistical significant differences in different weeks followed up (P=0.000). There was high correlation between the time of negative urine pregnancy test and the identified endometrial repair time by B ultrasonography (r=0.84, P=0.010). Conclusion: 2 weeks after medical abortion，the high correlation of the time of negative urine pregnancy test with the identified endometrial repair time by B ultrasonography. Therefore, the initial following up time of women after medical abortion should be postponed by the information management, and the following up procedure should be simplified, which can reduce women returning to hospital and improve the acceptability of women for medical abortion.
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