|
|
|
| Effect of different doses of levothyroxine for treating pregnant women with subclinical hypothyroidism on their pregnancy outcome |
| Luzhou Maternal and Child Health Care Hospital, Sichuan Province, 646000 |
|
|
|
|
Abstract Objective: To observe the clinical effect of different doses of levothyroxine for treating pregnant women with subclinical hypothyroidism, and to analyze its influence on their pregnancy outcomes. Methods: 210 pregnant women with subclinical hypothyroidism were enrolled as research subjects, and were divided into were divided into low dose group, middle dose group, and high dose group from January 2016 to January 2018. The women in the low dose group were given 50 μg/d levothyroxine, the women in the middle dose group were given 100 μg/d levothyroxine, and the women in the high dose group were given 150 μg/d levothyroxine. The incidence of adverse drug reactions during treatment, the adverse pregnancy outcomes, and the perinatal complications was observed, and the levels of serum TSH, FT3, FT4 and folic acid were compared before and after treatment. Results: The serum TSH levels of women in the middle dose group and high dose group were significant lower than those of women in the low dose group, while serum folic acid level was significant lower than that of women in the low dose group (P=0.000). The incidence of adverse pregnancy outcomes and the perinatal complications of women in the middle dose group and the high dose group were significant lower than those of women in the low dose group (P<0.05). There were no significant difference in serum TSH and folic acid levels, and the incidences of adverse pregnancy outcomes and perinatal complications between the high dose group and the middle dose group after treatment (P>0.05). The incidence of adverse drug reactions of women in the low dose group and the middle dose group were significant lower than that of women in the high dose group (P<0.05). Conclusion: Compared with those of women who using low dose (50μg/d) and high dose (150μg/d) of levothyroxine, middle dose of levothyroxine (100μg/d) can effectively reduce the serum TSH level of pregnant women with subclinical hypothyroidism, promote folic acid synthesis, prevent adverse pregnancy events, improve pregnancy outcome, and reduce the incidence of adverse drug reactions, and has high safety, which is worthy of clinical application.
|
|
|
|
|
|
|
|
|
