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| Pregnancy outcome predicted by estrogen and progesterone in the first trimester |
| Beijing Hospital, National Center of Gerontology, Beijing, 100730 |
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Abstract Objective: To study the possibility of serum estrogen and progesterone levels of pregnant women in the first trimester for predicting their pregnancy outcomes. Methods: The data of 184 pregnant women were retrospective analyzed. The serum levels of estrogen and progesterone of all included pregnant women at the 5th gestational week (35-41 days) were measured and the pregnant situations of women before 14 gestational weeks were observed. ROC curve was drawn through estrogen level, progesterone level, and estrogen level combined with progesterone level. Results: The serum E2 level of normal pregnant women at the 5th gestational week was 1923.4±747.9pmol/L, which was significant higher than that of women with abortion (1476.8±621.0pmol/L), and the cut off value, the sensitivity, and the specificity of E2 level was 1666.2pmol/L, 0.837, and 0.825, respectively. The serum P level of normal pregnant women at the 5th gestational week was 99.2±27.0nmol/L, which was significant higher than that of women with abortion (71.2±24.2nmol/L), and the cut off value, the sensitivity, and the specificity of P level was 77.9nmol/L, 0.809, and 0.839, respectively. The area under of the ROC of E2 level combined with P level was 0.901, the sensitivity was 0.851, and the specificity was 0.825. Conclusion: The levels of estrogen and progesterone of pregnant women in the first trimester is both good prognostic indicator for pregnancy outcomes, but combination of levels of estrogen and progesterone for predicting pregnancy outcomes is better.
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