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| The influences of the multimodal analgesia by parecoxib sodium combined with sufentanil on pain and stress response of patients after radical hysterectomy for cervical cancer |
| Beijing obstetrics and Gynecology Hospital,Capital Medical University, Beijing, 100006 |
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Abstract Objective: To explore the influences of multimodal analgesia by parecoxib sodium combined with sufentanil on pain and stress response of patients after cervical cancer radical operation. Methods: 89 patients after radical hysterectomy for cervical cancer were selected and divided into control group (47 cases) and observation group (42 cases) according to different anesthesia methods. All patients received sufentanil controlled analgesia after operation, and patients in observation group were given parecoxib sodium intravenously 30min before the after operation, while the patients in control group were given normal saline. Before anesthesia, 2h, 6h, 12h and 24h after operation, the levels of serum Cortisol (Cor), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) of all patients were detected by enzyme-linked immunosorbent assay (ELISA), and the levels of serum norepinephrine (NE) and epinephrine (E) were measured by radioimmunoassay. Visual analogue scale (VAS) was used to assess the degree of pain, Ramsay score was used to assess sedation degree. The incidences of adverse reactions of patients in the two groups were analyzed. Results: The number of patient-controlled press of analgesic and sufentanil dosage of patients in observation group were3.1±1.6 times and 0.059±0.005mg, which were significant less than those (0.065±0.007mg and 11.0±0.9 times) of patients in control group (P< 0.05). Postoperative 2h, 6h, 12h, and 24h, the VAS scores of the patients in observation group were significant lower than those of the patients in control group (P<0.05).The analgesic satisfaction rate of patients (92.9%) in observation group was significant higher than that (17.8%) of the patients in control group (P< 0.05). Compared with before anesthesia, the levels of serum NE, E, Cor, TNF-α, and CRP at postoperative 2h, 6h, 12h of all patients were significantly increased (P<0.05), and those of the patients in observation group increased more than those of patients in control group (P<0.05). The total incidence of postoperative analgesic adverse reaction of patients (2.4%) in observation group was significant lower than that (14.9%) of patients in control group (P<0.05). Conclusion: Multimodal analgesia by parecoxib sodium combined with sufentanil can significantly reduce the pain degree of patients after cervical cancer radical operation, can reduce body stress response and inflammatory reaction, and can decrease adverse reactions, which is better than that of patient-controlled analgesia by sufentanil used only.
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