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| Curative efficacy of Fuzheng huatan huoxue decoction for treating women with recurrent spontaneous abortion and insulin resistance |
| 1. The Second Clinical Medical College of Zhejiang Province Traditional Chinese Medicine University, Zhejiang Province, 310012; 2.Zhejiang Province Tongde Hospital |
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Abstract Objective: To study the curative efficacy of Fuzheng huatan huoxue decoction for treating women with recurrent spontaneous abortion and insulin resistance. Methods: 120 women with recurrent spontaneous abortion and insulin resistance were selected and divided into group A (35 cases), group B (40 cases), and group C (45 cases) by random number table method from January 2017 to January 2018. The women in the group A were given metformin for 3 months, the women in the group B were given Fuzheng huatan huoxue decoction metformin for 3 months, and women in the group C were given metformin combined with Fuzheng huatan huoxue decoction for 3 months. The changes of the body mass index value (BMI) and levels of HbA1, fasting insulin (FINS), insulin resistance index (HOMA IR), serum homocysteine (Hcy) of women before and after treatment, and the adverse reaction rate of women were compared among the three groups. Results: After treatment, the BMI value and levels of HbA1c, FINS, HOMA IR, Hcy of women in the three groups significantly decreased (P＜0.05). And the BMI value and levels of HbA1c, FINS, HOMA IR, Hcy of women in the C group were lowest (P＜0.05). The incidence of adverse reactions of group A, group B and group C was 8.6% (3/35), 2.5% (1/40) and 5.0% (2/45), respectively, which had no significant different (P＞0.05). Conclusion: Fuzheng huatan huoxue decoction combined with metformin can effectively regulate insulin resistance and hypercoagulable state of women, and has highly safety, so it is worth of popularizing.
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