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| Effect of Yougui pill on levels of serum TSH, FT4, TPOAb, and lipid, and pregnancy outcomes of pregnant women with TPOAb-positive subclinical hypothyroidism |
| Zhengzhou City people's hospital, Henan Province, 450000 |
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Abstract To investigate the effect of Yougui pill on levels of serum TSH, FT4, TPOAb, and lipid, and pregnancy outcomes of pregnant women with TPOAb positive subclinical hypothyroidism. Methods: 82 pregnant women with TPOAb positive subclinical hypothyroidism were divided into study group and control group. The women in control group were treated by levothyroxine sodium tablets, and the women in study group were treated by Yougui pill combined with levothyroxine sodium tablets. The levels of serum TSH, FT4, TPOAb, and lipid of all included women were detected before and after treatment, and the adverse pregnancy outcomes of all included women were recorded. Results: After treatment, the levels of TG, TC and LDL-C of women in the two groups decreased significantly (P<0.05), and those of women in study group were significant lower than those of women in control group (P<0.05). There was no significant change in FT4 level of women between before and after treatment (P>0.05). Though the rates of postpartum hemorrhage, fetal distress and abortion of women had no statistically significant different between the two groups (P>0.05), the rates of cesarean section, gestational hypertension, low birth weight and premature delivery of women in study group were significant lower than those of women in control group (P<0.05). Conclusion: Yougui pill combined with levothyroxine sodium tablets can decrease the levels of serum TSH and TPOAb of pregnant women with TPOAb positive subclinical hypothyroidism, and can improve their pregnancy outcomes.
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