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Abstract To investigate the levels of serum hypoxia inducible factor (HIF1α) and vascular endothelial growth factor (VEGF) of women with polycystic ovary syndrome (PCOS), and to explore the relationships between the levels of serum HIF1α or VEGF and insulin resistance (IR) of women. Methods: 70 women with PCOS were selected in study group from June 2015 to December 2017, and 70 healthy female volunteers were selected in control group during the same period. The related indicators of IR were detected by chemiluminescence, and the levels of serum HIF-1αand VEGF were measured by enzyme-linked immunosorbent assay (ELISA). IR was evaluated by insulin resistance index (HOMA-IR), and Pearson correlation analysis was used to analyze the relationships between level of serum HIF1α or VEGF and IR. Results: The value of luteinizing hormone/follicle stimulating hormone (LH/FSH), the level of testosterone (T) and fasting insulin (FINS), the value of HOMA-IR, and the levels of serum HIF1α and VEGF of women in study group were significant higher than those of women in control group (P<0.05). In study group, the levels of serum HIF1 and VEGF, and the value of HOMA-IR of women with BMI ≥25 kg/m2 were significant higher than those of women with BMI <23 kg/m2. Pearson correlation analysis showed that the levels of serum HIF1α and VEGF of women in study group were positively correlated with values of BMI, waist hip rate(WHR), LH/FSH, T, FINS, and HOMA-IR (P<0.05). Conclusion: The levels of serum HIF1 and VEGF of women with PCOS are up-regulated, which may be used as indicators for predicting their IR.
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