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| The change of the levels of plasma ADMA, NO, and NOS of women with gestational diabetes mellitus and the intervention efficacy of vitaimin D treatment |
| Zhengzhou People's Hospital，Henan Province, 450000 |
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Abstract To observe the change of levels of plasma asymmetric dimethylarginine (ADMA), nitric oxide (NO), nitric oxide synthase (NOS) of women with gestational diabetes mellitus (GDM), and to explore the intervention effect of vitamin D treatment. Methods: 108 women with GDM were selected and randomly divided into observation group and control group (54 cases in each group), and another 50 healthy pregnant women were selected in normal control group. The women in observation group were given vitamin D treatment additionally. The biochemical parameters, serum levels of 25-hydroxyvitamin D ［25(OH) D］, and plasma levels of ADMA, NO, NOS of women were detected and compared among the three groups. Results: The Body mass index (BMI), and levels of fasting blood glucose (FBG), plasma glucose (2hPG), Hemoglobin a1c (HbAlc), 25(OH)D, and ADMA, and homeostasis model assessment of insulin resistance (HOMA-IR)of women with GDM were significant higher than those of normal women (P<0.05), while plasma levels of NO and NOS of women with GDM were significant lower (P<0.05). The vitamin D lack/deficiency rate of women with GDM was significant higher than that of normal women (P<0.05). The 25(OH) D level of women with GDM was negative correlate to the ADMA level (r=-0.511, P<0.05), and was positive correlate to levels of NO and NOS (r=0.072, 0.151, P<0.05).There was no significant different in the levels of FBG and 2hBG of women with GDM between observation group and control group after treatment (P>0.05). The levels of HOMA-IR, HbAlc and ADMA of women in observation group were significant lower than those of women in control group (P<0.05), but the levels of 25(OH) D and NO and NOS were significant higher (P<0.05). Conclusion: Vitamin D deficiency and vascular endothelial dysfunction of women with GDM are common, Vitamin D supplementation during pregnancy is beneficial to improve insulin resistance and down-regulate levels of plasma ADMA, NO and NOS.
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