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| Analysis of serum levels of HbA1c, RBP4, and adiponectin of women with gestational diabetes mellitus during the third trimester and their correlation to pregnancy outcomes |
| Yihe Obstetrics and Gynecology Campus of Cangzhou People's Hospital，Hubei Province, 061000 |
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Abstract To investigate the correlation between levels of serum glycosylated hemoglobin (HbA1c), retinol binding protein 4 (RBP4), and adiponectin (ADP) of women with gestational diabetes mellitus (GDM) during the third trimester, and to explore the influence of the levels of HbA1c, RBP4, and adiponectin on pregnancy outcomes. Methods: From April 2014 to September 2015, 96 women with GDM who had over 28 gestational weeks were selected in observation group, and another 50 healthy pregnant women also over 28 gestational weeks were in control group. The levels of serum HbA1c, RBP4 and ADP of all women were detected, and the pregnancy outcomes of all women were recorded. Results: The levels of serum HbA1c and RBP4 of women in observation group were significant higher than those of women in control group (P<0.05), and the ADP level of women was significant lower than that of women in control group (P< 0.05). The levels of serum HbA1c, RBP4 and ADP of women in observation group were related to the rates of pregnancy hypertension, premature delivery, genital tract infection, fetal distress and macrosomia (P< 0.05). Logistic analysis showed that levels of serum HbA1c, RBP4 and ADP were risk factors of adverse pregnancy outcomes. Conclusion: In women with GDM during the third trimester, the levels of serum HbA1c and RBP4 are increased and ADP level is decreased, which is related to the pregnancy outcomes. The detection of serum HbA1c, RBP4 and ADP of women with GDM during the third trimester has great significance for judging and assessing pregnancy outcomes.
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