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| The efficacy of cyclosporin A for treating pregnant women with aplastic anemia and its influence on pregnancy outcomes |
| Qujing Maternal and Child HealthCare Hospital, Qujing City, Yunnan Province，655000 |
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Abstract To explore the efficacy of cyclosporin A for treating pregnant women with aplastic anemia, and to study its influence on pregnancy outcome. Methods: 170 pregnant women with aplastic anemiawere were selected and divided into observation group (n=90) and control group (n=80) by random number table method from April 2015 to April 2017. The women in control group were treated by kanglilong, and the women in observation group with were treated by cyclosporin A. The clinical efficacy, levels of WBC, PLT and VEGF, pregnancy outcomes, and rate of adverse reactions were compared between the two groups. Results: The total effective rate of observation group was 91.1%, which was significant higher than that (71.3%) of control group (P<0.05). The levels of WBC, PTL and VEGF of women in observation group were significant higher than those of women in control group (P<0.05). The incidences of gestational hypertension, postpartum hemorrhage, low birth weight, premature birth and neonatal asphyxia of women in observation group were significant lower than those of women in the control group (P<0.05). The total incidence of adverse reactions of women in observation group was 11.1%, which was significant lower than that (23.8%) of women in control group (P<0.05). Conclusion: Cyclosporin A treating pregnant women with aplastic anemia has significant efficacy, which can improve pregnancy outcomes with high safety, so it is worthy of clinical promotion.
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