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| The effect of insulin for treating pregnant women with gestational diabetes mellitus and its influence on TC, TBil and pregnancy outcomes |
| Shunyi District Hospital of Beijing, Beijing, 101300 |
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Abstract To investigate the effect of insulin for treating pregnant women with gestational diabetes mellitus (GDM), and to study influence of insulin on levels of serum cholesterol (TC), total bilirubin(TBil), and their pregnancy outcomes of women with GDM. Methods: 90 women with GDM were selected and divided into control group and observation group according to the random digital table method from March 2013 to March 2017 (45 cases in each group). The women in control group were given conventional treatment, while the women in observation group were given insulin except to conventional treatment. The incidences of preeclampsia and cesarean section, satisfactory rate of fasting blood glucose control (SRFBGC), levels of TC and TBil, and neonatal adverse outcomes were compared between the two groups. Results: The rate of cesarean section of women in observation group was significant lower than that of women in control group, while the SRFBGC was significant higher than that of women in control group (P<0.05). The serum level of TC ［(3.5±0.4) mmol/L］ of women in control group was significant higher than that［(2.2±0.2) mmol/L］ of women in observation group, but the serum level of TBil ［(10.3±1.1)μmol/L］ was significant lower than that［(13.7±1.7) μmol/L］ of women in observation group(P<0.05). The incidences of neonatal hypoglycemia, macrosomia, and respiratory distress in observation group were significant lower than those in control group (P<0.05). Conclusion: Insulin can reduce the rate of caesarean section of women with GDM, enhance the regulation of blood sugar, reduce renal damage, and improve the pregnancy outcomes.
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